Associazione Italiana Chimica e Tecnologia delle Ciclodestrine


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Gruppo Trapani

Research teams > Bari

Group Coordinator
Prof. Giuseppe Trapani
Tel: +39 0805442764
Fax: +39 0805442754
trapani[at]farmchim.uniba.it
a.lopedota[at]farmchim.uniba.it

Members

Prof. Massimo Franco; Dott.ssa Angela Lopedota; Dott.ssa Annalisa Cutrignelli; Dott.ssa Adriana Trapani.

Affiliation and Address
UniversitÓ degli Studi di Bari
FacoltÓ di Farmacia
Dipartimento Farmaco-Chimico
Campus Universitario, Via Orabona 4 - 70125 Bari

Curriculum Viate
Professor Trapani is full professor of Pharmaceutics and Biopharmaceutics at the Faculty of Pharmacy, University of Bari. In the past he also taught Pharmaceutical Technology at the same University. He is also a teacher of the PhD course in "Tecnologie delle Sostanze Biologicamente Attive", University of Palermo. He participates to the scientific committee for the division of research funds in pharmaceutical area and acts as a reviewer for a number of scientific journals.

Research interests

  • ROLE OF THE PERIPHERAL BENZODIAZEPINE RECEPTOR IN THE SELECTIVE ANTITUMOR DRUG DELIVERY AND IN THE IMAGING OF NEURODEGENERATIVE DISEASES
  • MICRO- AND NANO-ENCAPSULATION OF BIOLOGICALLY ACTIVE SUBSTANCES
  • IMPROVEMENT OF BIOPHARMACEUTICAL CHARACTERISTICS OF DRUGS BY USING CYCLODEXTRINS, SOLID DISPERSIONS, PRODRUGS AND CONJUGATES


Present projects

  • DELIVERY DI FARMACI ANTITUMORALI CONIUGATI CON LIGANDI DEL RECETTORE BENZODIAZEPINICO PERIFERICO;
  • APPLICAZIONI DI LIGANDI DEL RECETTORE BENZODIAZEPINICO PERIFERICO NELLA DIAGNOSTICA PER IMMAGINI DI PATOLOGIE NEURODEGENERATIVE;
  • RUOLO DI CICLODESTRINE NEL RILASCIO DI FARMACI PEPTIDICI E PROTEICI DA SISTEMI MICRO- E NANO-PARTICELLARI;
  • NUOVO METODO PER VALUTARE LA PERMEABILITA' INTESTINALE.


Expertise
CONIUGAZIONE DI FARMACI ANTITUMORALI;
PREPARAZIONE DI COMPLESSI CON CICLODESTRINE, DISPERSIONI SOLIDE, PROFARMACI POLIMERICI E NON.

Facilities
SPETTROMETRI FT IR, NMR, MASSA;
FLUORIMETRO
NANOSIZER
HPLC, GPC, SEC (RIVELAZIONE AD INDICE DI RIFRAZIONE)
DISSOLUTORI
LIOFILIZZATORI
CALORIMETRO DIFFERENZIALE A SCANSIONE
SPRAY-DRYER

Collaborations
COLLABORAZIONI RICHIESTE CON GRUPPI CON COMPETENZE IN MICROSCOPIA ELETTRONICA (SEM, TEM, CONFOCALE) E COLTURE CELLULARI

Publications

  • V. Laquintana, N. Denora, A. Lopedota, H. Suzuki, M. Sawada, M. Serra, G. Biggio, A.Latrofa, G. Trapani, and G. Liso N-Benzyl-2-(6,8-dichloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)-N-(6-(7-nitrobenzo[c][1,2,5]oxadiazol-4-ylamino)hexyl)acetamide as a New Fluorescent Probe for Peripheral Benzodiazepine Receptor and Microglial Cell Visualization. BIOCONJUGATE CHEMISTRY Published on Web 08/28/2007
  • N.DENORA, V.LAQUINTANA, A.LOPEDOTA, M.SERRA, L.DAZZI, G.BIGGIO, D.PAL, A.K.MITRA, A.LATROFA, TRAPANI G., G.LISO. (2007). Novel L-Dopa and Dopamine Prodrugs Containing a 2-Phenyl-imidazopyridine Moiety. PHARMACEUTICAL RESEARCH. vol. 24, pp. 1309-1324 ISSN: 0724-8741.
  • N.MARGIOTTA, R.OSTUNI, R.RANALDO, N.DENORA, V.LAQUINTANA, TRAPANI G., G.LISO, G.NATILE. (2007). Synthesis and Characterization of a Platinum (II) Complex Tethered to a Ligand of the Peripheral Benzodiazepine Receptor. JOURNAL OF MEDICINAL CHEMISTRY. vol. 50, pp. 1019-1027 ISSN: 0022-2
  • ADRIANA TRAPANI, VALENTINO LAQUINTANA, NUNZIO DENORA, ANGELA LOPEDOTA, ANNALISA CUTRIGNELLI, MASSIMO FRANCO, TRAPANI G., GAETANO LISO. (2007). Eudragit RS 100 microparticles containing 2-hydroxypropyl-?-cyclodextrin and glutathione: Physicochemical characterization, drug release and transport studies. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. vol. 30, pp. 64-74 ISSN: 0928-0987.
  • A.LOPEDOTA, A.CUTRIGNELLI, A.TRAPANI, G.BOGHETICH, N.DENORA, V.LAQUINTANA, TRAPANI G., G.LISO. (2007). Effects of different cyclodextrins on the morphology, loading and release properties of poly (DL-lactide-co-glycolide)-microparticles containing the hypnotic agent etizolam. JOURNAL OF MICROENCAPSULATION. vol. 24, pp. 214-224 ISSN: 0265-2048
  • A.LOPEDOTA, A.TRAPANI, A.CUTRIGNELLI, V.LAQUINTANA, N.DENORA, M.FRANCO, TRAPANI G., G.LISO. (2007). Effect of cyclodextrins on physico-chemical and release properties of Eudragit RS 100 microparticles containing glutathione. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY. vol. 57, pp. 425-432 ISSN: 1388-3127.
  • ANNALISA CUTRIGNELLI, NUNZIO DENORA, ANGELA LOPEDOTA, ADRIANA TRAPANI, VALENTINO LAQUINTANA, ANDREA LATROFA, TRAPANI G., GAETANO LISO. (2007). Comparative effects of some hydrophilic excipients on the rate of gabapentin and baclofen lactamization in lyophilized formulations. INTERNATIONAL JOURNAL OF PHARMACEUTICS. vol. 332, pp. 98-106 ISSN: 0378-5173.
  • ADRIANA TRAPANI, ANGELA LOPEDOTA, NUNZIO DENORA, VALENTINO LAQUINTANA, MASSIMO FRANCO, ANDREA LATROFA, TRAPANI G., GAETANO LISO. (2005). A rapid screening tool for estimating the potential of 2-hydroxypropyl-?-cyclodextrin complexation for solubilization purposes. INTERNATIONAL JOURNAL OF PHARMACEUTICS. vol. 295, pp. 163-175 ISSN: 0378-5173.
  • TRAPANI G., ANDREA LATROFA, NUNZIO DENORA, S. CELLAMARE, C. MACCALLINI, L. DAZZI, G. BIGGIO, GAETANO LISO. (2005). Preformulation studies and estimation of brain penetration for two alpidem analogues having anticonvulsant activity. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. vol. 15, pp. 331-337 ISSN: 1773-2247.
  • TRAPANI G., V. LAQUINTANA, N. DENORA, A. TRAPANI, A. LOPEDOTA, A. LATROFA, M. FRANCO, M. SERRA, M.G. PISU, I. FLORIS, E. SANNA, G. BIGGIO, G. LISO. (2005). Structure-activity relationships and effects on neuroactive steroids in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands. JOURNAL OF MEDICINAL CHEMISTRY. vol. 48, pp. 292-305 ISSN: 0022-2623.
  • ADRIANA TRAPANI, VALENTINO LAQUINTANA, ANGELA LOPEDOTA, MASSIMO FRANCO, ANDREA LATROFA, GIUSEPPE TALANI, ENRICO SANNA, TRAPANI G., GAETANO LISO. (2004). Evaluation of new propofol aqueous solutions for intravenous anesthesia. INTERNATIONAL JOURNAL OF PHARMACEUTICS. vol. 278, pp. 91-98 ISSN: 0378-5173.
  • TRAPANI G., V. LAQUINTANA, A. LATROFA, J. MA, K. REED, M. SERRA, G. BIGGIO, G. LISO, J. M. GALLO. (2003). Peripheral benzodiazepine receptor ligand. Melphalan conjugates for potential selective drug delivery to brain tumors. BIOCONJUGATE CHEMISTRY. vol. 14, pp. 830-839 ISSN: 1043-1802.



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