Associazione Italiana Chimica e Tecnologia delle Ciclodestrine


Go to content

Gruppo Vecchio

Research teams > Catania

Coordinator
Prof.ssa Graziella Vecchio
Tel: +39 0957385047
Fax: +39 095580138
gr.vecchio[at]unict.it

Members
Enrico Rizzarelli, Francesco Bellia, Valeria Lanza, Giuseppe Iacono

Affiliation and Address
Dipartimento di Scienze
Università di Catania

Curriculum Vitae
Graziella Vecchio, was born in Genoa 17.3.64.
She graduated in Chemistry at the University of Catania in 1988. In 1994 she was researcher at CNR. In 1996 she become a lecturer at the University of Catania. In 2001 she became Associate Professor of Inorganic Chemistry at the University of Catania. Since 2006 she has been full professor of Inorganic Chemistry at the University of Catania. Her research activity is attested by 77
publications, by a European patent and by two European patents pending. Her research activity
concentrates on: a) Synthesis and characterization of functionalized cyclodextrins; b) Molecular Recognition assisted by metal ions; c) Biomimetic systems and biological activity of coordination compounds; d) Glycoconjugates for Drug Delivery.

Research Projects
Synthesis of glycoconjugates
Organic and inorganic antioxidant systems.

Expertise
Organic synthesis of glucoconjugates. Chromatography, Spectroscopic Tecniche spettroscopiche (UV, CD, NMR).

Facilities
NMR (500 MHz), UV, CD spectrophotometer. Preparative and analytical HPLC. MS spectrometers (Maldi-Tof, ESI-MS). SPR. POtenziometry and calorimetry.

Publications:

  • V.Cucinotta, A. Giuffrida, D. La Mendola, G.Maccarrone, A. Puglisi, E.Rizzarelli, G. Vecchio 3-Amino derivative of -cyclodextrin: thermodynamics of copper(II) complexes and exploitation of its enantioselectivity in the separation of amino acid racemates by ligand exchange capillary electrophoresis J Chromatogr.B 800, 127 (2004).
  • P.Mineo, D. Vitalini, D. La Mendola, E. Rizzarelli, E. Scamporrino, G.Vecchio Coordination features of difunctionalized -cyclodextrins with carnosine. ESI-MS and spectroscopic investigations on 6A,6D-di-( -alanyl-L-histidine)-6A,6D-dideoxy- -cyclodextrin and 6A,6C-di-( -alanyl-L-histidine)-6A,6C-dideoxy- -cyclodextrin and their copper(II) complexes - J. Inorg. Biochem. 98, 254 (2004).
  • A.Puglisi, G.Tabbì, G.Vecchio Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity J.Inorg.Biochem. 98, 969 (2004).
  • S.Giuffrida, G.G.Condorelli, L.L.Costanzo, I. L.Fragala, G. Ventimiglia, G.Vecchio, Photochemical Mechanism of the Formation of Nanometer-Sized Copper by UV Irradiation of Ethanol Bis(2,4-pentanedionato)copper(II) Solutions. Chem.Mat. 16, 1260 (2004).
  • V.Cucinotta, A.Giuffrida, G.Maccarrone, M.Messina, A.Puglisi, A.Torrisi, G.Vecchio The 6-derivative of -cyclodextrin with succinic acid: a new chiral selector for CD-EKC J. Pharm.Biomed. Anal. 39, 1009 (2005).
  • V.Cucinotta, A. Giuffrida, G. Maccarrone, M. Messina, A. Puglisi, E. Rizzarelli, G.Vecchio Coordination Properties of 3-functionalized -cyclodextrins. Thermodynamic stereoselectivity of copper(II) complexes of the A,B-diamino derivative and its exploitation in LECE, Dalton Trans, 2005, 2731.
  • R. D'Agata, G.Grasso, G. Iacono, G. Spoto, G. Vecchio Lectin Recognition of a New SOD Mimic Bioconjugate Studied with Surface Plasmon Resonance Imaging, Org. Biomol. Chem., 2006, 610 (selected for publication on Chem. Biol.Virtual J. issue 4 (2006).
  • V.Cucinotta, A.Giuffrida, G.Maccarrone, M.Messina, G.Vecchio Ligand exchange capillary electrophoresis by cyclodextrin derivatives, a powerful tool for enentiomeric separations Electrophoresis 27, 1471 (2006).
  • D. La Mendola, E. Rizzarelli, A. Puglisi, G. Vecchio Sintesi di ciclodestrine funzionalizzate con etodolac come agenti di rilascio sito specifico brevetto MI2006A000894, maggio 2006.
  • A. M. Amorini, F. Bellia, G. Lazzarino, E. Rizzarelli, G. Vecchio Coniugati di trealosio con carnosina ad attività antiossidante, stabili all'idrolisi enzimatica. procedimento per la loro preparazione e composizioni farmaceutiche, Cosmetiche e Nutracetiche che li contengono MI2006A000690, aprile 2006.
  • F.Bellia, D.La Mendola, G.Maccarrone, P.Mineo, D.Vitalini, E.Scamporrino, S.Sortino, G.Vecchio, E.Rizzarelli Copper(II) complexes with the -cyclodextrin homocarnosine conjugates and their antioxidant activity Inorganica Chimica Acta , 360, 945 (2007).
  • D. La Mendola, E. Rizzarelli, A. Puglisi, G. Vecchio - Sintesi di ciclodestrine funzionalizzate con etodolac come agenti di rilascio sito specifico, MI2006A000894, maggio 2006.
  • S. Cuzzocrea, T. Genovese, M. Failla, G. Vecchio, M. Fruciano, E. Mazzon, R. Di Paola, C. Muia, C. La Rosa, N. Crimi, E. Rizzarelli, C. Vancheri, Protective effect of orally administered carnosine on bleomycin-induced lung injury. Am. J. Physiol. 292, L1095, (2007).
  • V. Cucinotta, A. Giuffrida, G.Grasso, G. Maccarrone, M. Messina, G. Vecchio High selectivity in new chiral separations of dansyl -amino acida by cyclodextrin derivatives in CD - EKC J.Cromatogr. A, 1155, 172 (2007).
  • V.Cucinotta, A.Giuffrida, G.Maccarrone, M.Messina, A.Puglisi, G.Vecchio Synthesis and NMR characterization of ?-alanine-bridged hemispherodextrin: a very efficient chiral selector in EKC Electrophoresis, 28, 2580 (2007).
  • A.Puglisi, R.Purrello, E.Rizzarelli, S.Sortino, G.Vecchio - Spectroscopic and self-association behavior of a porphyrin- -cyclodextrin conjugate - New J. Chem., 31, 1499 (2007).
  • F. Bellia, A. M. Amorini, D. La Mendola, G. Vecchio, B. Tavazzi, B. Giardina, V. Di Pietro, G. Lazzarino, E. Rizzarelli: New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity Eur. J. Med. Chem., 42, 910, (2007).



Back to content | Back to main menu