Associazione Italiana Chimica e Tecnologia delle Ciclodestrine


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Scienza del Farmaco

Research teams > Sassari

Coordinator of the research group:
Prof. GIUNCHEDI Paolo
Tel +39079228754
Fax +39079228715
pgiunc[at]uniss.it

Components:
ELISABETTA GAVINI, CLAUDIA JULIANO, GIOVANNA RASSU, GIANPIERA SPADA, COSSU MASSIMO

Affiliation and Address:
DIPARTIMENTO DI SCIENZE DEL FARMACO - UNIVERSITY OF SASSARI
VIA MURONI 23/A

Curriculum Vitae
The scientific responsible of the Research Unit is Full Professor in Pharmaceutical Technology at the Faculty of Pharmacy of the University of Sassari. His research experience in the field of Pharmaceutical Technology and of controlled release dosage forms is of more than fourteen years. More particularly his research activity dealt with topics such as improvement of the dissolution rate of drugs poorly soluble in water, preparation of compressed hydrophilic matrices for the constant release of drugs, formulation of drugs with pH-dependent solubility, design and preparation of pharmaceutical dosage forms for the pulsatile release of circadian drugs, study of the degradation processes of biodegradable drugs, study of bioadhesive systems. An important part of his research activity deals with the preparation, in vitro characterization and in vivo application of microspheres. The microparticulate drug delivery systems were intended for different routes of administration such as oral, ocular, parenteral, nasal.
He is author of more than 80 scientific publications, 5 patents and 130 congress communications (oral or poster presentations) / proceedings. He is member of the Controlled Release Society and of A.D.R.I.T.E.L.F. (Associazione Docenti e Ricercatori Italiani di Tecnica e Legislazione Farmaceutiche). He is Director of the Scuola di Specializzazione in Farmacia Ospedaliera of the University of Sassari.

Research topics:

  • Nasal transmucosal micro and nanoparticles for the systemic delivery and for the brain targeting of drugs
  • Solid Lipid Nanoparticles (SLNs) for the transcutaneous delivery of drugs
  • Vaginal chitosan gels
  • Buccal mucoadhesive tablets and films for the local delivery of antimicrobial drugs
  • Interaction between cyclodextrins and peptides
  • Controlled release dosage forms for veterinary use (bilayered-tablets for the oral delivery to ruminants)


Reaserch projects in progress:
Prin 2005: Microspheres and nanoparticles as carrier for the systemic and cerebral targeting of drugs by nasal administration.

Group Expertise:

  • Micro and nanoparticles preparation
  • Evaluation of particle size and particle size distribution of powders, suspensions, micro and nanoemulsions
  • Transmucosal and transcutaneous permeation studies
  • Studies on cell cultures


Equipment:

  • Spray-dryer
  • Dissolution equipment Erweka 7 vessel
  • Coulter laser diffraction
  • Nanosizer
  • Mixer Silverson
  • Mixer Ultraturrax
  • homogenizer Niro-Soavi
  • Stereomicroscopy
  • 2 HPLC UV- DAD
  • Gaschromatography
  • Spectrophotometers UV
  • FT-IR
  • Refrigerate centrifuge
  • Laboratory of microbiology for the studies on microrganism and cell cultures


References:

  • E.Gavini, G.Rassu, V.Sanna, M.Cossu, P.Giunchedi. (2005) Mucoadhesive microspheres for nasal administration of an antiemetic drug, metoclopramide: in-vitro/ex-vivo studies. J. Pharm. Pharmacol. 57, 287-294.
  • E.Gavini, L.Manunta, S.Giua, G.Achenza, P.Giunchedi. (2005) Spray-dried PDLLA microspheres containing Carboplatin for veterinary use: in-vitro and in-vivo studies. AAPS PharmSciTech 2005; 6 (1) Article 17 (http://www.aapspharmscitech.org).
  • E.Gavini, V.Sanna, R.Sharma, C.Juliano, M.Usai, M.Marchetti, J.Karlsen, P.Giunchedi (2005) Solid lipid microparticles (SLM) containing juniper oil as anti-acne topical carriers: preliminary studies. Pharmaceutical Development and Technology 10(4), 479-487
  • E.Gavini, MC.Alamanni, M.Cossu, P.Giunchedi. (2005) Tabletted microspheres containing Cynara scolymus (var. Spinoso sardo) extract for the preparation of controlled release nutraceutical matrices J.Microencapsulation 22 (5),487-499
  • E.Gavini, A.B.Hegge, G.Rassu, V.Sanna, C.Testa, G. Pirisino, J.Karlsen, P.Giunchedi (2006) Chitosan microspheres for the nasal administration of Carbamazepine: in vitro and in vivo studies Int. J. Pharmac. 307(1), 9-15
  • M.C. Bonferoni, G. Sandri, E. Gavini, S. Rossi, F. Ferrari, C. Caramella (2007) Microparticle systems based on polymer-drug interaction for ocular delivery of ciprofloxacin I. In vitro characterization, J. DRUG DEL. SCI. TECH., 17 (1) 63-68
  • Sanna V, Gavini E, Cossu M, Rassu G, Giunchedi P. (2007) Solid lipid nanoparticles (SLN) as carriers for the topical delivery of econazole nitrate: in-vitro characterization, ex-vivo and in-vivo studies. J Pharm Pharmacol. Aug;59(8):1057-64
  • Gavini E, Rassu G, Muzzarelli C, Cossu M, Giunchedi P (2007) Spray-dried microspheres based on methylpyrrolidinone chitosan as new carrier for nasal administration of metoclopramide. Eur J Pharm Biopharm. May 13; [Epub ahead of print]




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